What You Should Know About Taking Tramadol And Benadryl Simultaneously

What You Should Know About Taking Tramadol And Benadryl Simultaneously

Tramadol and Benadryl are listed in two different drug classes. Tramadol is a mild opioid and Benadryl is antihistamine, but this does not mean that it is okay to take these drugs at the same time. Below you will discover more information about these drugs and the dangers of taking them simultaneously.


Benadryl is an antihistamine and can be purchased as an over the counter medication. This drug is very effective in treating common cold and allergy symptoms, but many physicians are utilizing it to treat Parkinson’s disease, anxiety, and insomnia. Benadryl should not be prescribed to asthma sufferers, because it can potentially trigger or worsen the symptoms related to the respiratory disease, especially shortness of breath.


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Although tramadol is a mild opioid, it can still cause a wide variety of side effects including dry mouth, depression, fever, headache, drowsiness, irritability, and etc. It can also cause shortness of breath in individuals that have been diagnosed with respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD).


Taking Benadryl and tramadol together may cause severe respiratory suppression and agitation. If you are currently taking a routine dose of tramadol and begin to experience an upper respiratory infection, you should speak with your physician prior to taking Benadryl.


While many individuals will opt to treat their minor colds with Benadryl or other over counter antihistamines, this may not be the safest alternative. Speak with your physician, if you have been diagnosed with anxiety, ADHD, or asthma, before taking Benadryl or tramadol.

David Warren
David Warren

Pharmaceutical specialist at Wealthformyhealth.com
David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others.

David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.
David Warren

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1 Comment
  1. Nanny June 20, 15:25 Reply
    Thank you. This site helped me out a lot and gave me more information on the medications that I was worried about taking. Plus explained why I shouldn't take them together.
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