How Long Does Nyquil Stay In Your System? Detailed Answer

How Long Does Nyquil Stay In Your System? Detailed Answer

Whenever you have a sore throat or are dealing with allergies, if you’re going to reach for an over-the-counter medication don’t do it. There are many excellent medications that are perfect for these specific purposes. Nyquil is definitely one of the most effective. Of course, this medication isn’t entirely flawless. Consuming Nyquil does come with a few negative side effectives, which is why it is important to learn exactly how long does Nyquil last. Within this guide, you will be able to find out!

What Is Nyquil?

Before consuming Nyquil, it is absolutely essential to learn about the drug. What are the actual ingredients used, within this medication? This medication actually includes two medications. It is also known as Chlorpheniramine and Dextromethorphan. Half of the drug is an antihistamine and the other half is a cough suppressant. It is frequently used to combat the symptoms of colds, sore throats and other similar ailments. It should not be used, as a way to treat infections.

Potential Side Effects Of Nyquil

Although Nyquil is generally very safe, there are some side effects, which may be experienced. Below, you will be able to discover these side effects.

  • Constipation or diarrhea
  • Dizziness
  • Extreme drowsiness
  • Excitability and anxiousness
  • Anxiety and nervousness
  • Upset stomach and vomiting
  • Weakness
  • Loss of appetite
  • Hangover

These effects could potentially be dangerous, when driving a vehicle or operating machinery. Therefore, it is vital to make sure that you remain home, after consuming Nyquil.

How Long Does Nyquil Stay In Your System

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In order to understand exactly how long Nyquil lasts, it is absolutely vital to learn about the various ingredients in the drug. One of the ingredients found in Nyquil is Doxylamine, which is an antihistamine. This specific medication has a biological half-life or 6 to 12 hours. With this in mind, it is possible for the drug to remain in the system for a period of 12 to 24 hours. It should be known that the specifics will depend on a wide variety of different factors, including your age and metabolism. The medication will usually dissipate from a younger individual’s system much quicker and vice versa.


At the end of the day, Nyquil can be a truly beneficial medication, if you’re suffering from a cold or sore throat. Although the side effects are usually mild, you should be careful and make sure that you’re going to be home for 24 hours, after using Nyquil. This will help to ensure that you no longer feel the side effects, when you finally reintegrate back into society!

David Warren
David Warren

Pharmaceutical specialist at
David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others.

David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.
David Warren

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